Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious macrophage mTORC1 signalling and promote cardiovascular disease.
I mean dietary requirements do differ between ethnicities due to different levels of fat and muscle gain per “neutral” calorie, and it just so happens that Northern & Eastern European people (ie people traditionally considered White) have about a 20% lower tendancy to convert calories to fat over other things (bone, muscle etc.) when compared to the average human - South Asian people have about a 20% higher tendancy towards fat whereas most other ethnicities are very close to the average.
So excess protein being a greater issue in Western society (where thre are more White people) actually kind of tracks, as there’s going to be too much protein/amino acid availability as their bodies are more proactive about producing them from other food types anyway.
I mean dietary requirements do differ between ethnicities due to different levels of fat and muscle gain per “neutral” calorie, and it just so happens that Northern & Eastern European people (ie people traditionally considered White) have about a 20% lower tendancy to convert calories to fat over other things (bone, muscle etc.) when compared to the average human - South Asian people have about a 20% higher tendancy towards fat whereas most other ethnicities are very close to the average.
So excess protein being a greater issue in Western society (where thre are more White people) actually kind of tracks, as there’s going to be too much protein/amino acid availability as their bodies are more proactive about producing them from other food types anyway.