Works fine as a drug if fertilized…

To quote afroman:

So roll, roll, roll my joint, pick out the seeds and stems

Feelin’ high as hell, flyin’ through Palmdale, skatin’ on Dayton rims

Back in the day most weed came with seeds. Doesn’t really change the THC content, just means you gotta pick them out before hand, hence sinsemilla, which is preferable, because it has denser buds, and no seeds.