Hi all!

There is this song I play with my band which contains the following phrase: ^[1]

Or in ASCII, if you prefer:

e 5--5--|5--5--|7--7--|9--9--|
B -7--7-|-7--7-|-7--7-|-7--7-|
G --6--6|--6--6|--6--6|--6--6|
D ------|------|------|------|
A ------|------|------|------|
E ------|------|------|------|

The riff around that phrase wraps it four times with a little chord change at the end, and is itself played up to three times in a row, adding up to 12 repetitions of the above in one go. It’s played on a mostly clean channel, so muting the ringing strings is not an issue. ^[2]

It’s arguably not the hardest thing in the world to pull off for some bars, but having to play it for way over a minute straight puts serious strain on my wrist. After some time, I involuntarily stiffen up, now moving the better part of my forearm rather than only my hand. That of course impedes my speed and precision even more, and in the next part, I’ll be really exhausted - where I have to play a tight galloping rhythm, that I’m then often times unable to do well (enough).

What I’m looking for here is some advice on efficient technique, another picking pattern perhaps? I often times feel I practice the wrong thing. Until now, I tried u u u, which feels the most precise, but also tiring. It further makes me hit the highest string way harder than the others.
Currently, I practice d u u, which feels more ergonomic, but emphasizes the first note even more and becomes hard to control after a while.
Lately, I heard about “pick where you want to go next”. That would be u u d in my case, which feels really odd. Are you folks familiar with that approach, is it worth the time investment or do you have other suggestions?

P.S.: I could get away with hybrid picking because even though it’s also tiring for me doing it that fast for so long, it’s tiring other parts of my arm/hand which are not tested by the following part again. But fingerpicking sounds really different than with a pick and that doesn’t fit the song very well.