Two reasons, actually.
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It’s not their preferred preparation. All the replicated food is based on a pattern from an original recipe. It’s not adding flair or anything, it’s literally a copy of a dish made who knows how long ago. And that’s where the next reason comes from:
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Imagine eating some spicy pepper dish from, like, the 1940’s vs the same dish made today with spicer peppers. It wouldn’t be as spicy eating something that wasn’t, at the time, really selectively bred to be more spicy. If the recipe for the replicator is, like, hundreds of years old it would probably not be as potent as the same dish made with real ingredients.
I can imagine that the characters that have expressed disdain for replicated food probably get hit by both of these. It’s not the way they would preferred it to be made, and it’s also like eating vegetable jello salad in 2024.
My headcanon is that it’s entirely perception. Kind of like how plating the same food in a pretty way can affect how you rate it’s taste. The replicated food can be identical down to the molecule, but the knowledge that Sisko’s Dad handmade your dinner makes you think it’s tastier.