I work in bioinformatics and this is the kind of thing I keep trying to communicate to people in the field. Yes, these AI tools (like AlphaFold) are amazing, but if there’s a significant gap in their training data, the AI is going to have that gap too (most of the structures in the protein database were solved via X ray crystallography, which isn’t great for studying highly flexible or disordered proteins)
I work in bioinformatics and this is the kind of thing I keep trying to communicate to people in the field. Yes, these AI tools (like AlphaFold) are amazing, but if there’s a significant gap in their training data, the AI is going to have that gap too (most of the structures in the protein database were solved via X ray crystallography, which isn’t great for studying highly flexible or disordered proteins)