The way those mod loaders work for games that don’t have built in mod support is often by using Win32 APIs to inject the loader into the game process like a virus. It’s unlikely that injection mechanism and subsequently finding the relevant game code works correctly on Linux under Wine. Mod loaders that involve modifying the game files or placing extra DLLs in the game directory might work, but might take some extra tricks.
The way those mod loaders work for games that don’t have built in mod support is often by using Win32 APIs to inject the loader into the game process like a virus. It’s unlikely that injection mechanism and subsequently finding the relevant game code works correctly on Linux under Wine. Mod loaders that involve modifying the game files or placing extra DLLs in the game directory might work, but might take some extra tricks.