um… did my bio get deleted?

  • 243 Posts
  • 392 Comments
Joined 2 years ago
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Cake day: June 13th, 2023

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  • If you’d bothered to watch the video, you’d have noted that all the incidents in question involved batteries (4) or vehicles (1) being hauled in closed trailers, and that it was specifically about the issue of first responders being called to random trailer fires and having sub-optimal information that Li-ion batteries are involved.

    Also, Li-ion battery fires are often harder to put out than liquid fuel fires, take more resources to manage, and have a vastly higher chance of reignition.

    I’m very interested in electric vehicles and would love to own one (F150 Lightning house on wheels), but attempting to sugarcoat these facts will get people killed.





  • I quit reddit quite a while ago now, but I noticed over the past ~18 months or so when I would go slumming and poke around, r/DrugNerds has been almost entirely taken over by posts about recreational & nootropic drugs. I have absolutely nothing against discussing those - I wait with bated breath for new kratom research, for instance - but I like learning about all kinds of drugs, and wanted a place to post links when I’m doing a little light pharma reading for funsies, so … now we have this community :)






  • What’s interesting about this one is that they were trying to optimize binding at the site in the bacterial ribosome where florfenicol is known to bind, and indeed improved it, but in doing so appear to have stumbled upon an additional mode of action, by binding to a protein called arcB which is critical for aspects of arginine metabolism in many bacteria, arginine metabolism being very important for many normal cell functions. Arginine metabolism may play a role in maintenance of the bacterial cell membrane, and the bacteria did seem to be leaking their contents into the environment at a higher rate after application of the compound, among other effects.

    My interpretation here, but the fact that this compound is active at both the same site as the compound it was based on, and an entirely different site which also happens to be critical to bacterial metabolism, makes it very interesting from a drug resistance perspective, because a given strain of bacteria would potentially need more adaptations to successfully resist the drug than to resist a drug which is only active at one site.


  • Useful info, thank you. Once in a great while I have outages of a week or a little more, usually because something breaks when I just can’t rally the resources to fix it right away. Ideally this would never happen on infrastructure used to run an instance, but my hope is that various fedi platforms will be resilient to downtime on the order of 7-14 days before they entirely give up. I think it would be helpful to small and/or broke instance operators, and I would like a fedi with lots of little instances. :)