klenow

High tier is not so much about how hard something is to do, and more about the choices they have to make. For example, my L18 party is about to have choose between cutting the legs out from under the upcoming ilithid invasion, thereby saving millions of lives, or saving the paladin’s beloved homeland.

I work in drug development, and have done a lot of work in topical drug development, specifically for skin diseases. Psoriasis gets most of the attention, but there’s a lot of work being done on other skin diseases, as well

“Eczema” is kind of a catch-all term for a group of diseases, which is one of the reasons treatment is so difficult. One kind is often mistaken for (or even indistinguishable from) another. The most common, though, is atopic dermatitis (which is hilarious when you look up the etymology).

So that said… Have you tried JAK inhibitors? Ruxolitinib is one of the best ones, formulated as a cream called Opzelura. It’s at least good for flare ups.

Unfortunately, there aren’t really any good drugs for preventing it. If you want company on that one, talk to the asthma community.

But… There is work being done. I’ve worked on it. I’ve had companies spend millions on the work. I haven’t seen anything very promising, but maybe you can take some comfort that there are frustrated scientists working on it, and pharma companies poised to take all of your money once something is found.

A doctor seeing 36% O2 sat wouldn’t be concerned, they’d just pass the patient off to the coroner.

DM here. The biggest thing for me is when the players get emotionally engaged to the story and the beats. They fell actual hatred for the BBEG. They get so excited about a reveal that they all can’t talk for a minute. Something happens in game, and half the players are having a chat in the Discord in character, outside of game time. The reactions from the players are so rewarding.

The next best is when they come up with a solution to a problem in the game that I hadn’t even considered. It’s kind of fun to have to just say “OK. Hang on a minute. I was totally not prepared for y’all to try that, so I’m going to need to figure out what they impact of that is.” The players always get really excited about that; I think they love to stump me.

I’m 50. I’ve been gaming since my Dad won a Pong console at a work thing. I still love gaming, and so do a lot of other older men. Hell, the discussion at the lunch table at work today was about all the shit people are doing in Zelda. This was a group of 4 guys, all well over 30 (except one guy who just turned 30), all very successful…