Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid!
Any awful.systems sub may be subsneered in this subthread, techtakes or no.
If your sneer seems higher quality than you thought, feel free to cutānāpaste it into its own post, thereās no quota for posting and the bar really isnāt that high
The post Xitter web has spawned soo many āesotericā right wing freaks, but thereās no appropriate sneer-space for them. Iām talking redscare-ish, reality challenged āculture criticsā who write about everything but understand nothing. Iām talking about reply-guys who make the same 6 tweets about the same 3 subjects. Theyāre inescapable at this point, yet I donāt see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldnāt be surgeons because they didnāt believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I canāt escape them, I would love to sneer at them.
Canāt see the comments on there unfortunately, but interesting start to that piece. Will read it in parts today as I get time
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Ah my solution to this is different: if the things that I use to protect my shit are blocking some $x, ah well that can just get fucked then
Too exhausted by all the bullshit to try debug someoneās fuckery and specialcase them. Only exception is if itās something I need (and then Iāll do so very grumpily, and quite possibly loudly)
got you
i mean specifically this one
The rest of criticisms is in article
hahaha thatās an amazing comment, and yeah agreed/understood
also note that the big failures come from faulty biology, not from faulty chemistry. You can set innumerable piles of cash on fire if you choose to plug a wrong enzyme
elaborating on that. when you can hit a protein cleanly (without some side effects (called off-target, there are also on-target side effects)) but you hit wrong protein, this doesnāt have to be a complete loss, but itās likely. maybe you learn something, either about biology of that all or about something else that it interacts with, or maybe you have found a cure to some other disease instead. but this is the actual hard problem of drug development, especially when the biology of it all is little known. thereās a few of these drugs that started this way, fentanyl, viagra, thalidomide (as anticancer), minoxidil come to mind, and at worst you have a new tool for biologists. alphafold wonāt help with that
also note itās from january so not about the new thing