Highlights

• PFAS are found in polar bears and ringed seals in Greenland

• ∼90% of the East Greenlandic hunting community exceeds TWI for immune effects by 13-fold

• Multi-generational toxication will continue until 2090

• Need for non-toxic compounds and global phase-out

We estimate that the average inhabitant will continue to exceed established toxicity guidelines until 2090, posing the risk of immune suppression and disease susceptibility. Our findings emphasize the need for additional regulation of PFAS and the development of non-toxic sustainable compounds through international collaboration, not least through the Stockholm Convention.