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The original was posted on /r/science by /u/mvea on 2025-12-25 11:10:11+00:00.
Original Title: New study shows Alzheimer’s disease can be reversed to full neurological recovery—not just prevented or slowed—in animal models. Using mouse models and human brains, study shows brain’s failure to maintain cellular energy molecule, NAD+, drives AD, and maintaining NAD+ prevents or even reverses it.
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Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1
and another paper on the key compound, P7C3-A20: P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition https://pmc.ncbi.nlm.nih.gov/articles/PMC7959512/
